Welcome to LookChem.com Sign In|Join Free

Hebei Mojin Biotechnology Co.,Ltd

Diamond Supplier Enterprise Certification

Diamond
Supplier
6th
years

Search in the shop

  • Search in the shop
  • Search the station
Home>>Products>>High quanlity of RAD140 1182367-47-0

Products Categories

Product Certification&
Enterprise Certification

More Detail

Hebei Mojin Biotechnology Co.,Ltd

Country: China (Mainland)

Business Type:Trading Company

Mr.xing

Tel: 13231137666

Ms.bella gao

Tel: 15028179902

Ms.june wang

Tel: 13383610321

Ms.Angelia

Tel: +86 13288715578

Ms.emma

Tel: 13288715308

Ms.betty

Tel: +86 15028179772

Ms.may

Tel: +86 13315458396

Ms.april

Tel: 15103291926

Ms.cindy

Tel: 13315457394

Mobile: 13231137666

Tel: 13231137666

Fax:

URL: http://www.hbmojin.com

Province/state: Hebei

City: shijiazhuang

Street: room 1401,A building,Enjoy city,shijiazhuang city,hebei province,China

MaxCard:


qq
    x
  • Ms.betty
  • Ms.may
Contact Suppliers

High quanlity of RAD140 1182367-47-0

CAS NO.1182367-47-0

  • FOB Price: USD: 100.00-200.00 /Kilogram Get Latest Price
  • Min.Order: 1 Kilogram
  • Payment Terms: T/T
  • Available Specifications:

    comestic(1-20)Kilogramcomestic(20-40)Metric Ton

Contact Supplier

Product Details

Keywords

  • RAD140 1182367-47-0
  • Lowest price of RAD140 CAS NO.1182367-47-0
  • RAD140 White solid 99%;Testolone

Quick Details

  • ProName: High quanlity of RAD140 1182367-47-0
  • CasNo: 1182367-47-0
  • Molecular Formula: C20H16ClN5O2
  • Appearance: White solid
  • Application: RAD140 is a potent, orally bio-availab...
  • DeliveryTime: wihtin 5-7 days
  • PackAge: 25kg/bag
  • Port: shanghai
  • ProductionCapacity: 100000 Metric Ton/Day
  • Purity: 99%
  • Storage: cool and dry place
  • Transportation: By air or by ship or by express
  • LimitNum: 1 Kilogram
  • Grade: Industrial Grade
  • 1: 1

Superiority

RAD140 (also known as Testolone) is an oral nonsteroidal selective androgen receptor modulator (SARM) that cannot be converted to estrogen by aromatase.

It has been demonstrated that RAD140 has high AR affinity and target selectivity, showing marked tissue-selective AR agonist activity comparable to natural androgens in breast cancer cells, while lacking agonist activity in prostate cancer cells.
We have recently reported anti-tumor activity of RAD140 in multiple in vivo and in vitro models of AR/ER+ breast cancer as a single agent and in combination with inhibitors of CDK4/6 and mTOR.
Pharmacodynamic investigation indicates RAD140 acted as an AR agonist in breast cancer cells while suppressing ER signaling and reduced ESR1 mRNA expression.

RAD140 exhibited anti-tumor activity in patient-derived xenograft (PDX) models of AR/ER+ breast cancer, as single agent and in combination with inhibitors of CDK4/6 or mTOR
RAD140 inhibited ER signaling and ESR1 mRNA level in the HBCx-22 PDX model.

Details

Product Information

CAS: 1182367-47-0
MF: C20H16ClN5O2
MW: 393.83
EINECS: 1592732-453-0
Melting point  179-183oC
Boiling point  687.7±65.0 °C(Predicted)
density  1.41±0.1 g/cm3(Predicted)
storage temp.  -20°C Freezer
solubility  Chloroform (Slightly), DMSO (Slightly)
pka 13.76±0.20(Predicted)
form  Solid
color  White

Application area

Our services

Company information

Why choose us

lookchemhot productCASNew CAS Cas Database Article Data Chemical Catalog
Hot Product 5337-93-9 49851-31-2 94-24-6 62-44-2 137-58-6 593-51-1 103-63-9 100-09-4