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CAS NO.1379686-30-2
comestic(1-20)Kilogramcomestic(20-40)Metric Ton
SR-9009 is an agonist at nuclear receptor Rev-ErbA. Greatly diminishes VILI-induced lung edema, inflammatory cell infiltration and TNFα production in a rat lung injury model. SR-9009 suppresses atherosclerosis in a mouse model. Specifically lethal to cancer cells and oncogene-induced senescent cells with no effect on the viability of normal cells or tissues. Disrupts pain associated with osteoarthritis by reducing BMAL1 expression in bmal1f/fNav1.8CreERT mice.
Product Information
CAS: | 1379686-30-2 |
MF: | C20H24ClN3O4S |
MW: | 437.94 |
EINECS: | 1592732-453-0 |
Melting point | 79-81°C |
Boiling point | 547.2±45.0 °C(Predicted) |
density | 1.327±0.06 g/cm3(Predicted) |
storage temp. | -20° |
solubility | Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (up to 20 mg/ml). |
pka | 6.12±0.50(Predicted) |
form | solid |
color | Tan |
Uses | SR 9009 is a synthetic REV-ERB agonist that regulates circadian behavior and metabolism; has potential use in the treatment of sleep disorders and metabolic diseases. It is a lead compound for a new class of cancer drugs associated with the body’s circadian clock. |
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